Best CBD Oil for Depression in 2021

Written by 
Valerie Usher, Health & CBD Journalist.
|Check IconMedically reviewed by 
Eloise Theisen, RN, MSN, AGPCNP-BC.
|Last Updated:
* Leafreport may receive compensation. Here’s how we make money.
* Our review is consumer-focused only and we do not check or take a stand regarding medical effects.
* Statements regarding CBD products have not been evaluated by the Food and Drug Administration.
* Please advise your physician prior to each use of CBD.

More and more people are using CBD products to relieve common issues, including depression.

Early research suggests that CBD may have antidepressant effects. Besides, many people are wary of taking antidepressants because of their potential side effects and see CBD as a safer, natural alternative.

However, with so many CBD products available, it’s not easy to find the right one. To help you make a better choice, we compared dozens of brands to find the best CBD products for depression.

What does science say about CBD and depression?

Early studies suggest that CBD has antidepressant properties:

  • A 2020 case report of a boy suffering from severe depression, social phobia, and other issues linked to drug abuse found that CBD significantly improved his symptoms
  • A 2018 study of chronic cannabis users found that CBD capsules improved their depressive symptoms
  • A 2014 study of people suffering from cannabis withdrawal found that a drug containing similar doses of CBD and THC improved depression and other symptoms
  • CBD showed antidepressant effects in multiple animal studies
  • A 2021 book on the treatment of depression concluded that “preclinical evidence suggests it [CBD] can be a promising new antidepressant”

Nonetheless, researchers stress the need for high-quality human studies before we can say anything conclusive about CBD’s potential to help with depression.

How we chose these products

We review and compare hundreds of CBD products based on transparency, hemp quality, price, formula, and other criteria. For a full explanation of how we choose products for our best lists, check out this page.

All of our content is written and reviewed by a team of medical doctors, nurse practitioners, nutritionists, and other health experts knowledgeable about CBD and cannabis.

Why should you trust us?

Unlike other review sites, we use a standardized rating system to give every CBD product and brand an unbiased rating out of 100 points. This is calculated by using our database, which collects third-party lab test results, prices, additional ingredients, extract types, and other data for more than 3000 products.

We also act as a CBD industry watchdog by doing our own independent investigations. For example, we send CBD products for testing at an independent lab and publish our findings in market reports. We also collect and publish data on CBD prices to help you make an informed choice.

#1 Bests

Leafreport’s picks of the Best CBD oils for Depression

Drops+ Mind + Body 1500 mg
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency50 mg/ml
97
$99.99 $0.07 mg/CBD
Visit Site
Full Spectrum CBD Oil Tincture – 5000mg – 30ml
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency166.67 mg/ml
92
$240 $0.05 mg/CBD
Visit Site
Classic High Potency CBD Tincture 3000mg
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/ml
92
$70 $0.02 mg/CBD
Visit Site
Cannabinoid Tincture 2000 mg
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml
88
$99.99 $0.05 mg/CBD
Visit Site
CBD Softgels – 900mg
CBD Amount Score IconTotal CBD 900 mg
Available Bottle Sizes Score IconUnits 30 ml
Potency Score IconPotency30 mg/unit
88
$65.99 $0.07 mg/CBD
Visit Site
CBD Gummies 50mg
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconUnits 30 ml
Potency Score IconPotency50 mg/unit
71
$59.99 $0.04 mg/CBD
Visit Site
Platinum Rose – CBD Terpenes Oil - 500 mg
CBD Amount Score IconTotal CBD 500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency16.67 mg/ml
82
$69.99 $0.14 mg/CBD
Visit Site

Our picks

Best Overall — Plant People Drops+ Mind + Body

Plant People Drops+ Mind + Body 1500 mg

Overall Score
Product Review
97out of 100
$99.99 $0.07 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
20/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency50 mg/ml

Our top pick for depression goes to the mind + body drops from the New York brand Plant People. This strong full spectrum tincture provides 50 mg of CBD per ml.

 

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify that this tincture is free of contaminants and carries the right amount of CBD.

 

Hemp QualityIcon
Hemp Quality
20/20

Plant People sources its products from USDA certified organic Colorado hemp.

 

Extract TypeIcon
Extract Type
20/20

This CBD oil is made with full spectrum hemp extract, which is the most effective form of CBD.

 

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, this CBD oil contains multiple minor cannabinoids that work together with CBD.

 

PriceIcon
Price
10/10

This CBD oil costs $0.07 per mg of CBD, which is cheaper than average.

Pros: Cons:
  • High potency
  • Comprehensive third party testing
  • USDA organic certified
  • No flavored options

Best Potency — CBDistillery Full Spectrum CBD Oil

CBDistillery Full Spectrum CBD Oil Tincture – 5000mg – 30ml

Overall Score
Product Review
92out of 100
$240 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency166.67 mg/ml

Some people need higher doses of CBD, which means they need to look for products with higher CBD concentrations. We recommend the full spectrum CBD oil from CBDistillery, which is available in a very high potency of 167 mg/ml.

 

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the potency and purity of this tincture.

 

Hemp QualityIcon
Hemp Quality
15/20

CBDistillery uses organic Colorado hemp to make its products. The company is also certified by the U.S. Hemp Authority, highlighting its adherence to strict hemp production standards.

 

Extract TypeIcon
Extract Type
20/20

This tincture is made with full spectrum hemp extract, which is considered the most effective form of CBD.

 

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests show that CBDistillery’s CBD oil contains multiple minor cannabinoids.

 

PriceIcon
Price
10/10

With a price of $0.05 per mg of CBD, this tincture is significantly cheaper than average.

Pros: Cons:
  • Very high potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • No flavored options

Best Value — Lazarus Naturals High Potency CBD Tincture

Lazarus Naturals Classic High Potency CBD Tincture 3000mg

Overall Score
Product Review
92out of 100
$70 $0.02 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/ml

If you want to get the bang for your buck, you can’t go wrong with Lazarus Naturals. The company’s high potency full spectrum tincture provides 3000 mg of CBD (50 mg/ml) at an extremely low price.

 

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the potency and purity of this CBD oil.

 

Hemp QualityIcon
Hemp Quality
15/20

Lazarus Naturals grows its organic hemp in central Oregon, whereas most companies buy their hemp from other producers.

 

Extract TypeIcon
Extract Type
20/20

This CBD oil is made with full spectrum hemp extract, providing the full benefits of hemp.

 

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, this tincture carries multiple minor cannabinoids that work in synergy with CBD.

 

PriceIcon
Price
10/10

Lazarus Naturals’ high potency tincture costs $0.02 per mg of CBD, which is one of the lowest prices you’ll find anywhere. The company also offers free shipping over $25 and a 60% discount to veterans, low-income families, and people with disabilities.

Pros: Cons:
  • Exceptionally low price
  • High CBD potency
  • Comprehensive third party testing
  • Lacks higher potencies

Best THC Free — Medterra Broad Spectrum Cannabinoid Tincture

Medterra CBD Cannabinoid Tincture 2000 mg

Overall Score
Product Review
88out of 100
$99.99 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
16/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml

Some people have to avoid THC because of drug testing and other reasons. For that case, we recommend the broad spectrum cannabinoid tincture from Medterra. It’s available in three flavors and has a strong potency of 67 mg/ml.

 

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the purity and potency of this broad spectrum CBD oil.

 

Hemp QualityIcon
Hemp Quality
15/20

Medterra’s products are sourced from organic Kentucky hemp. They’re also certified by the U.S. Hemp Authority, which means Medterra follows strict hemp industry quality standards.

 

Extract TypeIcon
Extract Type
16/20

This CBD oil contains broad spectrum hemp extract, which is free of THC but maintains all of the other beneficial components of full spectrum CBD.

 

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, this tincture is rich in minor cannabinoids which work together with CBD.

 

PriceIcon
Price
10/10

With a price of $0.05 per mg of CBD, this product costs less than most broad spectrum tinctures.

Pros: Cons:
  • High CBD potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • None

Best Capsules — Farmacy Bliss Full Spectrum CBD Softgels

Farmacy Bliss CBD Softgels – 900mg

Overall Score
Product Review
88out of 100
$65.99 $0.07 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
34/40
Hemp Quality
17/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 900 mg
Available Bottle Sizes Score IconUnitsNA
Potency Score IconPotency30 mg/ml

Thanks to their ease of use and precise dosing, capsules are a popular alternative to CBD oil. We recommend the full spectrum CBD softgels from Farmacy Bliss. They contain 30 mg of CBD with 30 caps per bottle.

 

Quality AssuranceIcon
Quality Assurance
34/40

Third party tests confirm the potency and purity of these capsules.

 

Hemp QualityIcon
Hemp Quality
17/20

Farmacy Bliss’ softgels are sourced from USDA certified organic American hemp. The company is also certified by the U.S. Hemp Authority.

 

Extract TypeIcon
Extract Type
20/20

These softgels are made with full spectrum hemp extract, which is the most effective form of CBD.

 

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests confirm that these capsules contain multiple minor cannabinoids that work in synergy with CBD.

 

PriceIcon
Price
10/10

With a cost of $0.07 per mg of CBD, these capsules are cheaper than average.

Pros: Cons:
  • USDA organic certified
  • U.S. Hemp Authority certified
  • Comprehensive third party testing
  • Lacks higher potencies

Best Gummies — Five CBD Full Spectrum Gummies

five CBD CBD Gummies 50mg

Overall Score
Product Review
71out of 100
$59.99 $0.04 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
19/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconUnitsNA
Potency Score IconPotency50 mg/ml

If you’re looking to use CBD in the delicious form of gummies, we recommend Five CBD. The company offers one of the only proper full spectrum CBD gummies on the market. Better yet, they have a high strength of 50 mg (with 5 mg of THC).

 

Quality AssuranceIcon
Quality Assurance
19/40

Third party tests confirm that these gummies are free of contaminants, although they might have more CBD than advertised.

 

Hemp QualityIcon
Hemp Quality
15/20

Five CBD’s products are sourced from organic American hemp.

 

Extract TypeIcon
Extract Type
20/20

Unlike most CBD gummies, these are made from full spectrum hemp extract. As such, they may be more effective.

 

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, these gummies contain THC and multiple minor cannabinoids.

 

PriceIcon
Price
10/10

These edibles cost $0.04 per mg of CBD, which is quite cheap for gummies, especially when they’re full spectrum.

Pros: Cons:
  • Full spectrum formula
  • Comprehensive third party testing
  • High potency
  • THC content may be high for some people

**Use caution with this product as it may cause impairment**

Best Vape Product — CBDfx Terpene Vape Liquid

CBDfx Platinum Rose – CBD Terpenes Oil - 500 mg

Overall Score
Product Review
82out of 100
$69.99 $0.14 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
12/20
Additional ingredients
7/10
Price
8/10
CBD Amount Score IconTotal CBD 500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency16.67 mg/ml

If you prefer immediate relief, vaping CBD can be a good option. We recommend the terpene vape liquid from CBDfx, which has four flavors and two potencies: 500 mg (17 mg/ml) and 1000 (33 mg/ml).

This unique vape juice is infused with a blend of terpenes from various cannabis strains, making it more effective than standard pure CBD vape oils.

If you don’t have a vape, CBDfx also sells a dedicated CBD vape kit.

 

Quality AssuranceIcon
Quality Assurance
40/40

Third-party tests confirm the potency and purity of this vape juice.

 

Hemp QualityIcon
Hemp Quality
15/20

CBDfx products are derived from organic Kentucky hemp.

 

Extract TypeIcon
Extract Type
12/20

This vape juice is formulated with pure CBD.

 

Additional ingredientsIcon
Additional ingredients
7/10

Unlike most vape juices, this product also contains a blend of cannabis terpenes that may have beneficial properties.

 

PriceIcon
Price
8/10

At $0.07-0.10 per mg of CBD, this vape oil costs less than most CBD e-liquids.

 

Pros: Cons:
  • Most reputable CBD vape vendor
  • Multiple flavors
  • Added terpenes
  • CBD vape kit available
  • Not full-spectrum

How to choose the best CBD for depression

With so many CBD products available, it’s not easy to choose the best one for depression. Here are some helpful tips:

  • Third party testing: Reputable brands send their products for testing at an independent lab to verify their safety and CBD content. You should only buy third party tested products.
  • Consumption method: CBD can be taken in a variety of ways, each with its advantages and disadvantages. For example, some people prefer to vape CBD because it works right away.
  • Type of CBD: There are three types of CBD; isolate, full spectrum, and broad spectrum. Full spectrum is considered the most effective whereas the other two types are better when you need to avoid THC.
  • Dosage: The right amount of CBD is different for everyone. You should start with a small dose and raise it slowly. The next time you shop, you can match your dosage to the product with the right potency.

Check out our detailed guide for a full explanation of how to find reputable CBD companies and choose the best products.

Safety and side effects

CBD has been the subject of intense research, showing that it’s a safe and well-tolerated compound. Its side effects are minor and include:

  • Tiredness and drowsiness
  • Diarrhea and nausea
  • Low blood pressure and lightheadedness
  • Changes in appetite or weight
  • Dry mouth

CBD can also interact with many prescription drugs. As such, it’s best to talk with your doctor before taking it, especially if you’re already using antidepressants or other prescription medication.

Nonetheless, most people are unlikely to experience side effects because they’ve only been reported in studies using high oral doses of pure CBD.

Legality

Hemp derived CBD products (with 0.3% or less THC) are federally legal in the United States. However, a few states have more restrictive laws. Some ban CBD completely or only allow THC free products, so it’s best to research the particular state you’re curious about.

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About The Authors
Valerie Usher
Valerie Usher
Health & CBD Journalist
Valerie Usher is a health journalist who covers the topics of CBD, mental health, women’s health and careers. In 2017, she graduated from Miami University in Oxford, Ohio with a degree in Integrative Studies. Her concentrations were in health and society. In college, Valerie excelled in scientific research study and soon began reading studies on CBD. She’s been ghostwriting and content writing about CBD and cannabis since 2017. Valerie is mainly interested in the way CBD aids in mental health.
Eloise Theisen
Eloise Theisen
RN, MSN, AGPCNP-BC
Eloise Theisen is a board certified Adult Geriatric Nurse Practitioner who specializes in cannabis therapy. For over 20 years, Eloise has worked primarily with cancer, dementia and chronic pain patients. In the last 6 years, Eloise has focused her efforts on cannabinoid therapies. Eloise has worked with over 6500 patients to help them effectively treat age-related and chronic illness with cannabis.
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