Best CBD Oil for Anxiety and Stress in 2021

Written by 
Gleb Oleinik, CBD Journalist.
|checkMedically reviewed by 
Leonard Haberman, MD & Chemist.
|Last Updated:
CBD for anxiety
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* Please advise your physician prior to each use of CBD.

You’re probably familiar with cannabidiol (CBD), one of the main active components of cannabis. Unlike tetrahydrocannabinol (THC), CBD doesn’t cause intoxication.

CBD products are used by a growing number of people to help with a wide variety of health issues, including anxiety.

Although more studies are needed, research has shown that CBD has potent anxiolytic (anxiety reducing) effects that can help with occasional anxiety as well as specific anxiety disorders.

But with so many products to choose from, it can be tough to make a choice. That’s why we compared different brands to find the best CBD products for anxiety.

What does science say about CBD and anxiety?

Multiple clinical studies have shown that CBD can relieve various types of anxiety:

  • In a 2019 Japanese study, CBD oil decreased anxiety in teenagers with social anxiety disorder (SAD) and avoidant personality disorder (AVPD)
  • In a 2011 Brazilian study, CBD capsules reduced anxiety induced by public speaking in people with SAD
  • In another 2019 study out of Colorado, CBD capsules improved anxiety in people with sleep or anxiety disorders
  • A 2020 review paper of all the available evidence on the use of CBD for anxiety concluded that “CBD has a promising role as alternative therapy in the management of anxiety disorders

Overall, the findings are quite promising and confirm anecdotal reports of CBD users. Still, researchers stress the need for further high quality studies to figure out the best CBD dosage for anxiety and other specifics.

How we chose these products

Our team of medical doctors, nutritionists, and other health experts chose these products based on their quality, transparency, price, and other criteria. For example, all of the products we recommend are tested by a third party lab to verify their potency and safety.

We also consider factors relevant to anxiety. For example, we suggest THC free options because some people are sensitive to THC and may feel anxious from a large dose of a full spectrum product. Check here for more details on how we choose products.

We also use an objective ranking system that rates brands and products out of 100 points.

#1 BestLeafreport’s picks of the Best CBD oils

Our picks

Best Overall — NuLeaf Naturals

Nuleaf Naturals Full Spectrum Hemp CBD Oil 3000mg
Full Spectrum Hemp CBD Oil 3000mg
Overall ScoreProduct Review
93

Quality Assurance40/40
Hemp Quality18/20
Extract Type20/20
Additional ingredients7/10
Price8/10
Price:   $239Price CBD/mg:   $0.08Total CBD:   3000 mgPotency:  60 mg/mlExtract Type:  Full SpectrumAvailable Bottle Sizes:   50 ml

Our overall top pick for anxiety is the full spectrum CBD oil from NuLeaf Naturals. This established Colorado brand is known for offering high quality full spectrum products.

Its full spectrum tincture has a high potency of 60 mg of CBD per ml for a total of 1800 mgMultiple bottle sizes are available.

Quality Assurance

Third party tests confirm that this CBD oil has no contaminants and provides as much CBD as advertised.

Hemp Quality

Like all NuLeaf Naturals products, this tincture is sourced from organic hemp cultivated in Colorado.

Extract Type

This is a proper full spectrum CBD tincture that provides the complete benefits of hemp.

Additional Ingredients

According to third party testing, this CBD oil contains multiple minor cannabinoids.

Price

With a cost of $0.10 per mg of CBD, you’re getting a price that’s about average for CBD tinctures.

Pros: Cons:
  • High CBD potency
  • Comprehensive third party testing
  • No flavored options

Best THC Free — CBDistillery

CBDistillery Broad Spectrum CBD Oil Tincture - 1000mg - 30ml
Broad Spectrum CBD Oil Tincture - 1000mg - 30ml
Overall ScoreProduct Review
82

Quality Assurance34/40
Hemp Quality15/20
Extract Type16/20
Additional ingredients7/10
Price10/10
Price:   $55Price CBD/mg:   $0.06Total CBD:   1000 mgPotency:  33.3 mg/mlExtract Type:  Broad SpectrumAvailable Bottle Sizes:   30 ml

Some people, and especially those suffering from anxiety, are sensitive to THC. This means they can experience an increase in anxiety even from the small amount of THC (<0.3%) present in a full spectrum product.

For those people, we recommend the broad spectrum CBD oil from CBDistillery, which carries 33 mg of CBD per ml, for a total of 1000 mg.

Quality Assurance

Third party tests verify that this CBD oil is free of THC and contaminants, although it may contain more CBD than stated on the label.

Hemp Quality

CBDistillery is a popular brand that’s certified by the U.S. Hemp Authority for adhering to high quality standards. Its tinctures are made from organic Colorado hemp.

Extract Type

This tincture is made with broad spectrum CBD, which has no THC while retaining other beneficial hemp compounds.

Additional Ingredients

Aside from CBD, this broad spectrum CBD oil contains multiple cannabinoids.

Price

With a price of $0.06 per mg of CBD, this CBD oil is cheaper than average.

Pros: Cons:
  • High CBD potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • No flavored options

Best Potency — Endoca

Endoca CBD Oil 150Mg CBD/ml (Strong)
CBD Oil 150Mg CBD/ml (Strong)
Overall ScoreProduct Review
98

Quality Assurance40/40
Hemp Quality17/20
Extract Type20/20
Additional ingredients10/10
Price8/10
Price:   $150.5Price CBD/mg:   $0.1Total CBD:   1500 mgPotency:  150 mg/mlExtract Type:  Full SpectrumAvailable Bottle Sizes:   10 ml

Everyone’s ideal CBD dosage is different. If you find that you need large doses, we recommend the strong CBD oil from Endoca, one of the oldest and most respected CBD companies in the world.

This full spectrum tincture has a very high potency of 150 mg of CBD per ml, with a total of 1500 mg of CBD in the 10 ml bottle. You can choose the natural or chocolate mint flavor.

Quality Assurance

According to third party and in house tests, this tincture contains the correct amount of CBD and is free of pesticides and other potential contaminants.

Hemp Quality

This CBD oil is sourced from organic Danish hemp cultivated by Endoca and the local farmers it partners with.

Extract Type

This is a high quality full spectrum CBD oil so you’re getting the most out of hemp’s benefits.

Additional Ingredients

Our third party test study found that Endoca’s tinctures contain multiple minor cannabinoids aside from CBD, which is a great sign.

Price

Endoca’s CBD oil costs $0.10 per mg of CBD, which is an average price point.

Pros: Cons:
  • Very high CBD potency
  • Third party and in house testing
  • Small bottle size
  • The unflavored option has a strong hemp taste

Best Value — Lazarus Naturals

Lazarus Naturals Classic High Potency CBD Tincture 3000mg
Classic High Potency CBD Tincture 3000mg
Overall ScoreProduct Review
95

Quality Assurance40/40
Hemp Quality18/20
Extract Type20/20
Additional ingredients7/10
Price10/10
Price:   $70Price CBD/mg:   $0.02Total CBD:   3000 mgPotency:  50 mg/mlExtract Type:  Full SpectrumAvailable Bottle Sizes:   60 ml

Lazarus Naturals is our top pick for the value oriented shopper. The company’s high potency (50 mg/ml) tincture provides 3000 mg of CBD at an exceptionally low price.

Quality Assurance

According to third party tests, this CBD oil is free of contaminants and contains an accurate amount of CBD.

Hemp Quality

Lazarus Naturals’ products are derived from organic hemp cultivated in central Oregon.

Extract Type

This CBD oil contains full spectrum hemp extract, the most effective form of CBD.

Additional Ingredients

Third party potency tests show multiple cannabinoids aside from CBD, which is a sign of a high quality full spectrum extract.

Price

Lazarus Naturals’ high potency CBD tincture costs only $0.02 per mg of CBD, which is far cheaper than the average market price. The company also offers a 60% discount for veterans, people with disabilities, and low income families.

Pros: Cons:
  • Exceptionally low prices
  • High CBD potency
  • Comprehensive third party testing
  • Multiple flavors and sizes
  • Lacks higher potencies

Best Capsules — PlusCBD 

PlusCBD Oil Plus CBD Softgel Capsules 30ct 15MG Gold Formula
Plus CBD Softgel Capsules 30ct 15MG Gold Formula
Overall ScoreProduct Review
93

Quality Assurance40/40
Hemp Quality18/20
Extract Type20/20
Additional ingredients7/10
Price8/10
Price:   $39.99Price CBD/mg:   $0.09Total CBD:   450 mgPotency:  15 mg/mlExtract Type:  Full Spectrum

Many people prefer to use CBD capsules because of their convenience. Our top pick for anxiety is the extra strength softgels from PlusCBD, one of the first American CBD brands.

They provide 15 mg of full spectrum CBD in each softgel with 60 softgels per bottle.

Quality Assurance

Third party and in house tests confirm that these capsules carry the advertised amount of CBD and are free of contaminants. Additionally, PlusCBD holds the FDA’s self affirmed Generally Recognized As Safe (GRAS) status, which means its products passed rigorous safety testing.

Hemp Quality

Unlike most American brands, PlusCBD sources its CBD from organic hemp grown in Europe. PlusCBD is also certified by the U.S. Hemp Authority.

Extract Type

These vegan friendly capsules are made with full spectrum hemp extract, providing the full benefits of hemp.

Additional Ingredients

According to potency tests, PlusCBD’s capsules contain multiple minor cannabinoids.

Price

PlusCBD’s softgels cost $0.08 per mg of CBD, which is on the lower end of the average cost of CBD capsules.

Pros: Cons:
  • U.S. Hemp Authority certified
  • Third party and in house testing
  • Relatively low strength

Best Gummies — Fab CBD

Fab CBD CBD Chews
CBD Chews
Overall ScoreProduct Review
87

Quality Assurance40/40
Hemp Quality17/20
Extract Type12/20
Additional ingredients10/10
Price8/10
Price:   $59Price CBD/mg:   $0.08Total CBD:   750 mgPotency:  25 mg/mlExtract Type:  Isolate

If you’re after the delicious convenience of gummies, we recommend Fab CBD. The company’s fruit flavored chews carry 25 mg of pure CBD per piece, with 30 gummies per container.

Quality Assurance

Third party tests confirm that these gummies are free of contaminants and contain an accurate amount of CBD.

Hemp Quality

The CBD is sourced from organic hemp grown in Colorado.

Extract Type

Like most gummies, these sweets are made with pure CBD isolate.

Additional Ingredients

These gummies are free of artificial sweeteners and made with organic, vegan friendly ingredients.

Price

Fab CBD’s gummies cost $0.08 per mg of CBD, which is close to the average price for CBD gummies.

Pros: Cons:
  • Medium strength potency
  • Comprehensive third party testing
  • Only one container size

Best Vape Product — Koi CBD

Koi CBD Koi CBD - CBD Vape Juice - Blue Koi - 1000mg
Koi CBD - CBD Vape Juice - Blue Koi - 1000mg
Overall ScoreProduct Review
77

Quality Assurance40/40
Hemp Quality15/20
Extract Type12/20
Additional ingredients0/10
Price10/10
Price:   $59.99Price CBD/mg:   $0.06Total CBD:   1000 mgPotency:  33.33 mg/mlExtract Type:  IsolateAvailable Bottle Sizes:   30 ml

For those who prefer immediate anxiety relief, vaping CBD can be a fast acting alternative to CBD oil. We recommend the CBD vape juice from California’s Koi CBD, a reputable brand known for its vape products.

It comes in a 30 ml bottle with 1000 mg of CBD, giving it a medium strength potency of 33 mg per ml.

Quality Assurance

Third party tests confirm that you’re getting as much CBD as you paid for and a safe, pesticide free product.

Hemp Quality

This vape juice is made from organic hemp cultivated in Colorado.

Extract Type

Like most CBD vape products, this e-liquid is made with CBD isolate.

Additional Ingredients

This vape juice has a simple yet straightforward formula consisting of CBD dissolved in a 50%/50% mix of VG/PG with added flavoring.

Price

This vape juice costs $0.06 per mg of CBD, which is cheaper than most CBD vape e-liquids.

Pros: Cons:
  • Medium strength potency
  • Comprehensive third party testing
  • Great price
  • Lacks high potency options

How to choose the best CBD for anxiety

It can be difficult to choose a CBD product for anxiety with so many options. We put together some tips to help you make an educated choice:

  • Third party testing: Reputable brands send their products for testing at an independent lab to verify their safety and CBD content. You should only buy third party tested products.
  • Consumption method: CBD can be taken in different ways, each with its advantages and weaknesses. For example, some people prefer to vape CBD because it offers instant effects.
  • Type of CBD: There are three types of CBD; isolate, full spectrum, and broad spectrum. Full spectrum is considered the most effective but some people may prefer the other two types.
  • Dosage: The right amount of CBD is different for everyone. You should start with a small dose and raise it slowly. The next time you buy CBD, you can match your dosage to the optimal product potency.

We have a detailed guide for a full explanation of how to find reputable CBD companies and choose the best product for yourself.

Safety and side effects

CBD has been extensively studied, and the results suggest that it’s a safe and well tolerated compound. While it can cause some side effects, they’re usually minor, and include:

  • Tiredness and drowsiness
  • Diarrhea and nausea
  • Low blood pressure
  • Lightheadedness
  • Changes in appetite or weight
  • Dry mouth

CBD can also interact with prescription medications. The good news is that these effects were only reported by studies using high doses of pure CBD. As such, they’re not likely to happen for most people.

Still, we recommend consulting your doctor or another qualified healthcare professional before using CBD, especially if you’re taking prescription medicine.

Legality

CBD products derived from hemp (cannabis containing 0.3% or less THC) are legal under federal law in the United States. However, you also have to consider individual state laws. For example, some states ban CBD entirely or only allow products with zero THC.

You can also take CBD while driving. However, if you use a full spectrum product, you may have a detectable amount of THC in your body. That means you can test positive for marijuana if you get pulled over in a state where it’s illegal.

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About The Authors
Gleb Oleinik
Gleb Oleinik
CBD Journalist
Gleb Oleinik is a freelance health writer and Journalist from Vancouver, Canada. He’s read thousands of research studies about various supplement ingredients, enabling him to translate complex health information into simple language. Gleb specializes in CBD and has personally tried and reviewed dozens of CBD products. He’s knowledgeable about the ins and outs of the CBD industry as well as the science and research behind this popular natural remedy.
Leonard Haberman
Leonard Haberman
MD & Chemist
Dr. Leonard Haberman is a physician and chemist who has been involved in solving chemical and medical problems for 43 years. He graduated from New York University as a dual major in chemistry and biology and went on to obtain a PhD in chemistry from the University of Minnesota where his focus was synthetic methods. He spent 18 years with the Shell organization, working in a mixture of technical and business roles. He returned to the university in 2005, graduating with an MD degree in 2009. He has published in the open literature and in the proprietary literature of the Shell organization. He holds two patents and currently works as a consultant, assisting clients with projects within the disciplines of medicine and chemistry that have potential business applications.
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