CBD oil for Seizures and Epilepsy in 2021

Written by 
Gleb Oleinik, CBD Journalist.
|Check IconMedically reviewed by 
Eloise Theisen, RN, MSN, AGPCNP-BC.
|Last Updated:
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* Our review is consumer-focused only and we do not check or take a stand regarding medical effects.
* Statements regarding CBD products have not been evaluated by the Food and Drug Administration.
* Please advise your physician prior to each use of CBD.

Some people turn to CBD as an alternative treatment for seizures and epilepsy.

Although most of the high-quality research evidence is limited to rare, severe types of treatment-resistant epilepsy, studies suggest that CBD has antiepileptic effects.

The only problem is that choosing the right CBD oil for seizures can be difficult. You have to look for high-quality products that contain the right type and amount of CBD.

That’s why we compared dozens of brands to find the best CBD products for seizures and epilepsy.

What does science say about CBD, seizures, and epilepsy?

Rigorous clinical trials have shown that CBD can relieve epileptic seizures associated with three severe types of childhood epilepsy: Lennox-Gastaut syndrome (LGS), Dravet syndrome, and tuberous sclerosis complex (TSC):

  • In one 2017 study of children with Dravet syndrome, CBD significantly reduced seizures, with 5% of patients becoming seizure-free
  • In a 2018 study of children and adults with LGS, CBD led to a significant reduction (average reduction was 43.9% fewer) in seizures
  • In a 2021 study of children with TSC, CBD treatment significantly reduced seizures compared to placebo
  • A 2018 review paper found that CBD-rich, whole-plant cannabis extracts were up to four times more effective at improving treatment-resistant epileptic seizures than pure CBD, and also produced fewer side effects

The evidence is so convincing that the FDA approved the pure CBD drug Epidiolex for treating these three types of epilepsy. However, more studies are needed to substantiate CBD’s efficacy in other types of seizures.

How we chose these products

We review and compare hundreds of CBD products from dozens of brands based on price, hemp quality, transparency, reputation, and other criteria.

We also consider factors relevant to seizures. For example, we only recommend high-potency products because seizures typically require high doses of CBD.

For a full explanation of how we choose products for our best lists, check out this page.

All of our content is written and reviewed by a team of medical doctors, nurse practitioners, nutritionists, and other health experts knowledgeable about CBD and cannabis.

Why should you trust us?

Unlike other review sites, Leafreport uses a standardized rating system to give every CBD product and brand an unbiased rating out of 100 points.

This score is calculated by using our database, which collects third-party lab test results, prices, additional ingredients, extract types, and other data for more than 3000 products.

We also act as a CBD industry watchdog by doing our own independent investigations.

For example, we send CBD products for testing at an independent lab and publish our findings in market reports. We also collect and publish data on CBD prices to help you make an informed choice.

#1 Bests

Leafreport’s picks of the Best CBD oil for Seizures and Epilepsy

CBD Oil 150Mg CBD/ml (Strong)
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 10 ml
Potency Score IconPotency150 mg/ml
95
$129 $0.09 mg/CBD
Visit Site
Full Spectrum CBD Oil Tincture – 5000mg – 30ml
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency166.67 mg/ml
92
$240 $0.05 mg/CBD
Visit Site
RSO CBD Oil 5000mg
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 50 ml
Potency Score IconPotency100 mg/ml
92
$120 $0.02 mg/CBD
Visit Site
Cannabinoid Tincture 2000 mg
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml
88
$99.99 $0.05 mg/CBD
Visit Site
Softgel Capsules 50mg 30ct Maximum Strength Formula
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/unit
95
$119.99 $0.04 mg/CBD
Visit Site
CBD Gummies 25mg
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnits 30 ml
Potency Score IconPotency25 mg/unit
92
$39.99 $0.05 mg/CBD
Visit Site
Blueberry Gelato Vape Juice 1500
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 15 ml
Potency Score IconPotency100 mg/ml
82
$30.99 $0.02 mg/CBD
Visit Site

Our picks

Best Overall — Endoca Strong CBD Oil

Endoca CBD Oil 150Mg CBD/ml (Strong)

Overall Score
Product Review
95out of 100
$129 $0.09 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
17/20
Extract Type
20/20
Additional ingredients
10/10
Price
8/10
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 10 ml
Potency Score IconPotency150 mg/ml

Our top recommendation for seizures is the strong CBD oil from Endoca, one of the oldest and most respected brands in the world. This full spectrum tincture comes with a very high potency of 150 mg/ml.

Quality AssuranceIcon
Quality Assurance
40/40

Third party and in-house tests confirm that this CBD oil contains the advertised amount of CBD and lacks contaminants.

Hemp QualityIcon
Hemp Quality
17/20

Endoca grows its own hemp in partnership with local farmers, whereas most companies source it from other producers.

Extract TypeIcon
Extract Type
20/20

This CBD oil contains full spectrum hemp extract, which is considered the most effective form of CBD.

Additional ingredientsIcon
Additional ingredients
10/10

Third party and our own independent tests show that Endoca’s CBD oil is rich in minor cannabinoids that work together with CBD.

PriceIcon
Price
8/10

Endoca’s strong CBD oil costs $0.10 per mg of CBD. Compared to other tinctures, this price is considered average.

Pros: Cons:
  • Very high CBD potency
  • Third party and in house testing
  • Small bottle size
  • Strong hemp taste

Best Potency — CBDistillery Full Spectrum CBD Oil

CBDistillery Full Spectrum CBD Oil Tincture – 5000mg – 30ml

Overall Score
Product Review
92out of 100
$240 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency166.67 mg/ml

Seizures typically require some of the highest doses of CBD out there, which means you might need an exceptionally strong product. We recommend the full spectrum CBD oil from CBDistillery, which is available in a very high potency of 167 mg/ml.

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the strength and purity of this CBD oil.

Hemp QualityIcon
Hemp Quality
15/20

CBDistillery’s products are sourced from organic Colorado hemp. The company is also certified by the U.S. Hemp Authority, which means it follows strict hemp production practices.

Extract TypeIcon
Extract Type
20/20

This CBD oil contains full spectrum hemp extract, which may be more effective than pure CBD.

Additional ingredientsIcon
Additional ingredients
7/10

According to third party testing, there are many minor cannabinoids in this tincture.

PriceIcon
Price
10/10

With a price of $0.05 per mg of CBD, this tincture is cheaper than average.

Pros: Cons:
  • Very high potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • No flavored options

Best Value — Lazarus Naturals CBD RSO

Lazarus Naturals RSO CBD Oil 5000mg

Overall Score
Product Review
92out of 100
$120 $0.02 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 5000 mg
Available Bottle Sizes Score IconBottle Size 50 ml
Potency Score IconPotency100 mg/ml

Our top value pick goes to Lazarus Naturals. The company’s CBD Rick Simpson Oil (RSO) provides 5000 mg of full spectrum CBD at an exceptionally low price. It also has a high potency (100 mg/ml) which is ideal for seizures.

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the potency and purity of this unique CBD concentrate.

Hemp QualityIcon
Hemp Quality
15/20

Instead of getting its hemp from other producers like most brands, Lazarus Naturals grows most of its organic hemp on a farm in central Oregon.

Extract TypeIcon
Extract Type
20/20

This RSO contains full spectrum hemp extract, which maximizes the benefits of CBD.

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, this tincture carries multiple minor cannabinoids that add to the effects of CBD.

PriceIcon
Price
10/10

This RSO costs $0.03 per mg of CBD, which is much lower than most tinctures and concentrates. On top of that, Lazarus Naturals offers free shipping over $25 and a 60% discount to veterans, low-income families, and people with disabilities.

Pros: Cons:
  • Exceptionally low price
  • High CBD potency
  • Comprehensive third party testing
  • None

Best THC Free — Medterra Broad Spectrum Cannabinoid Tincture

Medterra CBD Cannabinoid Tincture 2000 mg

Overall Score
Product Review
88out of 100
$99.99 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
16/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml

If you’re sensitive to THC or have to pass drug tests for work, you’ll need to look for a THC free product. We recommend the broad spectrum cannabinoid tincture from Medterra, which carries a high 10:1 ratio of CBD to minor cannabinoids.

It has a strong potency of 67 mg/ml and comes in three flavors.

Quality AssuranceIcon
Quality Assurance
40/40

According to third party testing, this tincture is free of contaminants and contains the advertised amount of CBD.

Hemp QualityIcon
Hemp Quality
15/20

Medterra uses organic Kentucky hemp to make its products. The company is also certified by the U.S. Hemp Authority, which means it follows strict hemp industry standards.

Extract TypeIcon
Extract Type
16/20

This tincture is made with broad spectrum hemp extract, which is free of THC but maintains the other active components of the whole plant.

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests verify that this tincture is rich in minor cannabinoids that work in synergy with CBD.

PriceIcon
Price
10/10

At $0.05 per mg of CBD, this product is priced lower than most broad spectrum tinctures.

Pros: Cons:
  • High CBD potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • None

Best Capsules — PlusCBD Max Strength CBD Softgels

PlusCBD Oil Softgel Capsules 50mg 30ct Maximum Strength Formula

Overall Score
Product Review
95out of 100
$119.99 $0.04 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
18/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/ml

We don’t recommend capsules as your only CBD product for seizures because they tend to have lower absorption and potency than oils.

Having said that, our top pick is the max strength softgels from PlusCBD, which carry 50 mg of full-spectrum CBD, with 30 capsules per bottle.

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests confirm the potency and purity of these capsules.

Hemp QualityIcon
Hemp Quality
18/20

Unlike most American companies, PlusCBD sources its products from organic European hemp, which has the advantage of a long history of cultivation. PlusCBD is also certified by the U.S. Hemp Authority.

Extract TypeIcon
Extract Type
20/20

These capsules contain full spectrum hemp extract, which is considered the most effective form of CBD.

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests show that these capsules contain multiple minor cannabinoids which add to the effects of CBD.

PriceIcon
Price
10/10

These capsules cost $0.05 per mg of CBD, which is significantly cheaper than average.

Pros: Cons:
  • U.S. Hemp Authority certified
  • Comprehensive third party and in-house testing
  • High potency
  • Lacks higher potencies

Best Gummies — Five CBD Full Spectrum Gummies

five CBD CBD Gummies 25mg

Overall Score
Product Review
92out of 100
$39.99 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnitsNA
Potency Score IconPotency25 mg/ml

Our go-to choice here is the full spectrum gummies from Five CBD. They have a high potency of 50 mg (with 5 mg of THC) and an option for 25 mg, and are made with full spectrum hemp extract.

However, similar to capsules, gummies shouldn’t be your only CBD product for seizures because they’re less effective than oils.

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests verify the purity of these gummies, and they passed the test for CBD levels with results within the acceptable 10% variance.

Hemp QualityIcon
Hemp Quality
15/20

Five CBD uses organic American hemp to make its products.

Extract TypeIcon
Extract Type
20/20

These gummies are made from full spectrum hemp extract, unlike most gummies on the market. This means they may be more effective.

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests show that these gummies contain THC and multiple minor cannabinoids, which work in synergy with CBD.

PriceIcon
Price
10/10

These gummies cost $0.04 per mg of CBD. That’s quite low compared to most gummies on the market, especially since they’re full spectrum.

Pros: Cons:
  • Full spectrum formula
  • Comprehensive third party testing
  • High potency
  • THC content may be high for some people

**Use caution with this product as it may cause impairment**

Best Vape Product — Funky Farms CBD Vape Juice

Funky Farms Blueberry Gelato Vape Juice 1500

Overall Score
Product Review
82out of 100
$30.99 $0.02 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
5/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 15 ml
Potency Score IconPotency100 mg/ml

Vaping CBD is the best option if you want immediate effects. We recommend the 1500 mg vape juice from Florida’s Funky Farms.

This high-potency e-liquid contains full-spectrum CBD and comes in four flavors: blueberry gelato, apple jack pear, peach tangie, and mango sherbert.

Quality AssuranceIcon
Quality Assurance
40/40

Third-party tests verify the potency and purity of this vape juice.

Hemp QualityIcon
Hemp Quality
5/20

The CBD used in this product comes from Oregon hemp.

Extract TypeIcon
Extract Type
20/20

This vape juice contains full-spectrum CBD, which is considered more effective than pure CBD isolate.

Additional ingredientsIcon
Additional ingredients
7/10

Third-party tests show THC and several minor cannabinoids, which work in synergy with CBD.

PriceIcon
Price
10/10

Funky Farms’ vape juice costs only $0.02 per mg of CBD, which is quite cheap for CBD e-liquid.

Pros: Cons:
  • Full-spectrum formula
  • Exceptionally low price
  • High potency
  • Comprehensive-third party testing
  • Unclear if hemp is organic
  • Third-party tests are outdated

How to choose the best CBD for seizures and epilepsy

Here are some tips to help you find the best CBD product for seizures and epilepsy:

  • Third party testing: Reputable brands send their products for testing at an independent lab to verify their safety and CBD content. You should only buy third party tested products.
  • Consumption method: CBD can be taken in a variety of ways, each with its advantages and disadvantages. For example, capsules and gummies have lower absorption than oils, which makes them less effective.
  • Type of CBD: There are three types of CBD; isolate, full spectrum, and broad spectrum. Research evidence suggests that full spectrum CBD is significantly more effective at relieving epileptic seizures than pure CBD.
  • Dosage: Seizures typically require some of the highest CBD dosages out of any condition, so it’s best to look for high potency products.

Check out our detailed guide for a full explanation of how to find reputable CBD companies and choose the best products.

Safety and side effects

Research has demonstrated that CBD is a safe compound with few and minor side effects. The most common issues reported in studies include:

  • Tiredness and drowsiness
  • Diarrhea and nausea
  • Low blood pressure and lightheadedness
  • Changes in appetite or weight
  • Dry mouth

CBD can also interact with prescription drugs, including anti-seizure medications. That’s why we recommend talking with your doctor before using it, especially if you’re already taking antiepileptic medicine.

Having said that, CBD’s side effects are unlikely to happen to most people because they’ve only been reported by studies using high oral doses of purified CBD.

Legality

Hemp derived CBD products (with 0.3% or less THC) are federally legal in the United States. However, a few states have more restrictive laws. Some ban CBD completely or only allow THC free products, so it’s best to research the particular state you’re curious about.

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About The Authors
Gleb Oleinik
Gleb Oleinik
CBD Journalist
Gleb Oleinik is a freelance health writer and Journalist from Vancouver, Canada. He’s read thousands of research studies about various supplement ingredients, enabling him to translate complex health information into simple language. Gleb specializes in CBD and has personally tried and reviewed dozens of CBD products. He’s knowledgeable about the ins and outs of the CBD industry as well as the science and research behind this popular natural remedy.
Eloise Theisen
Eloise Theisen
RN, MSN, AGPCNP-BC
Eloise Theisen is a board certified Adult Geriatric Nurse Practitioner who specializes in cannabis therapy. For over 20 years, Eloise has worked primarily with cancer, dementia and chronic pain patients. In the last 6 years, Eloise has focused her efforts on cannabinoid therapies. Eloise has worked with over 6500 patients to help them effectively treat age-related and chronic illness with cannabis.
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