Best CBD oil and Topicals for Inflammation in 2021

Written by 
Gleb Oleinik, CBD Journalist.
|Check IconMedically reviewed by 
Eloise Theisen, RN, MSN, AGPCNP-BC.
|Last Updated:
* Leafreport may receive compensation. Here’s how we make money.
* Our review is consumer-focused only and we do not check or take a stand regarding medical effects.
* Statements regarding CBD products have not been evaluated by the Food and Drug Administration.
* Please advise your physician prior to each use of CBD.

CBD oil and other CBD products are growing popular as a way to relieve anxiety, pain, insomnia, and other health concerns.

Research suggests that CBD has anti-inflammatory effects that may help with a variety of conditions with an inflammatory component, such as arthritis.

CBD is also safe and can be used in the long term, in contrast to many common anti-inflammatory drugs. Still, more evidence for its anti-inflammatory effects in specific conditions is needed.

But with so many products available, finding the right one isn’t easy. That’s why we put together this list of the best CBD products for inflammation.

What does science say about CBD and inflammation?

CBD’s anti-inflammatory effects have been demonstrated in a variety of conditions that involve chronic inflammation:

  • A 2019 study found that CBD-rich cannabis extract improved ulcerative colitis, whereas placebo had no effect
  • A 2019 pilot study found that cannabis with a 2:1 ratio of CBD: THC has positive effects in people with severe dementia, which is linked to brain inflammation
  • Similarly, a 2014 clinical study reported that CBD improved quality of life for people with Parkinson’s disease, while placebo did not
  • A 2006 study of Sativex, a whole-plant cannabis drug that contains equal amounts of CBD and THC, reported reduced pain in rheumatoid arthritis patients
  • According to a 2015 review paper, CBD showed anti-inflammatory effects in animal studies of diabetes, IBD, arthritis, edema (swelling), brain inflammation, liver injury, and lung diseases.

Overall, research suggests that CBD has potent anti-inflammatory properties that can help with various inflammatory conditions. Still, more high-quality studies are needed to confirm and better understand CBD’s effects.

How we chose these products

We review and compare hundreds of CBD products from dozens of brands based on price, hemp quality, transparency, reputation, and other criteria.

We also consider factors relevant to inflammation. For example, some of the products we suggest are formulated with turmeric and other anti-inflammatory ingredients.

For a full explanation of how we choose products for our best lists, check out this page. We also use an unbiased ranking system for rating brands and products out of 100 points.

All of our content is written and reviewed by a team of medical doctors, nurse practitioners, nutritionists, and other health experts knowledgeable about CBD and cannabis.

#1 Bests

Leafreport’s picks of the Best CBD oil and Topicals for Inflammation

Serious Relief + Turmeric Tincture 66mgdose (1oz)
CBD Amount Score IconTotal CBD 1980 mg
Available Bottle Sizes Score IconBottle Size30 ml - 60 ml
Potency Score IconPotency66 mg/ml
93
$149.99 $0.08 mg/CBD
Visit Site
CBD Oil 150Mg CBD/ml (Strong)
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 10 ml
Potency Score IconPotency150 mg/ml
95
$129 $0.09 mg/CBD
Visit Site
Classic High Potency CBD Tincture 3000mg
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/ml
92
$70 $0.02 mg/CBD
Visit Site
Cannabinoid Tincture 2000 mg
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml
88
$99.99 $0.05 mg/CBD
Visit Site
83
$59.99 $0.12 mg/CBD
Visit Site
CBD Softgels With Curcumin
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnits 30 ml
Potency Score IconPotency25 mg/unit
83
$89.95 $0.12 mg/CBD
Visit Site
CBD Gummies 25mg
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnits 30 ml
Potency Score IconPotency25 mg/unit
92
$39.99 $0.05 mg/CBD
Visit Site
Platinum Rose – CBD Terpenes Oil - 500 mg
CBD Amount Score IconTotal CBD 500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency16.67 mg/ml
85
$49.99 $0.1 mg/CBD
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Our picks

Best Overall — Receptra Naturals Serious Relief Tincture

Receptra Naturals Serious Relief + Turmeric Tincture 66mgdose (1oz)

Overall Score
Product Review
93out of 100
$149.99 $0.08 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
10/10
Price
8/10
CBD Amount Score IconTotal CBD 1980 mg
Available Bottle Sizes Score IconBottle Size30 ml - 60 ml
Potency Score IconPotency66 mg/ml

Our top pick for inflammation is the serious relief tincture from Colorado’s Receptra Naturals. This mint berry-flavored CBD oil has a high potency of 66 mg/ml and also contains turmeric, a research backed anti-inflammatory herb.

Quality AssuranceIcon
Quality Assurance
40/40

According to third party test results, this tincture is free of pesticides and other contaminants and contains the advertised amount of CBD.

Hemp QualityIcon
Hemp Quality
15/20

Receptra grows its hemp on an organic farm in Colorado.

Extract TypeIcon
Extract Type
20/20

This CBD oil contains full-spectrum CBD extract.

Additional ingredientsIcon
Additional ingredients
10/10

Receptra’s tincture not only contains multiple minor cannabinoids but also turmeric, an anti-inflammatory herb.

PriceIcon
Price
8/10

Receptra’s CBD oil costs $0.08 per mg of CBD, which is slightly cheaper than the average price for full spectrum tinctures.

Pros: Cons:
  • Added turmeric
  • High CBD potency
  • Comprehensive third party testing
  • One flavor option

Best Potency — Endoca Strong CBD Oil

Endoca CBD Oil 150Mg CBD/ml (Strong)

Overall Score
Product Review
95out of 100
$129 $0.09 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
17/20
Extract Type
20/20
Additional ingredients
10/10
Price
8/10
CBD Amount Score IconTotal CBD 1500 mg
Available Bottle Sizes Score IconBottle Size 10 ml
Potency Score IconPotency150 mg/ml

Strong CBD oils contain more CBD per ml and are ideal for people who need to take larger doses. If you’re looking for a high potency CBD oil, we recommend Denmark’s Endoca.

Its strong full spectrum tincture has a very high potency of 150 mg/ml.

Quality AssuranceIcon
Quality Assurance
40/40

Third party and in-house tests verify the potency and purity of Endoca’s strong CBD oil.

Hemp QualityIcon
Hemp Quality
17/20

Whereas most CBD brands source their hemp from other producers, Endoca directly grows its organic hemp in Denmark in partnership with local farmers.

Extract TypeIcon
Extract Type
20/20

This tincture contains full-spectrum CBD extract.

Additional ingredientsIcon
Additional ingredients
10/10

Third party tests and our independent testing show that Endoca’s tinctures are rich in minor cannabinoids that work in synergy with CBD.

PriceIcon
Price
8/10

Endoca’s strong CBD oil costs $0.10 per mg of CBD, which is considered an average price.

Pros: Cons:
  • Very high CBD potency
  • Third party and in house testing
  • Small bottle size
  • Strong hemp taste

Best Value — Lazarus Naturals High Potency CBD Tincture

Lazarus Naturals Classic High Potency CBD Tincture 3000mg

Overall Score
Product Review
92out of 100
$70 $0.02 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 3000 mg
Available Bottle Sizes Score IconBottle Size 60 ml
Potency Score IconPotency50 mg/ml

If you want to get the best value for your money, you can’t go wrong with Lazarus Naturals. The company’s full spectrum, high potency (50 mg/ml) tincture provides 3000 mg of CBD at an exceptionally low price. It comes in multiple sizes and flavors.

Quality AssuranceIcon
Quality Assurance
40/40

According to third party testing, this CBD oil contains an accurate amount of CBD and has no pesticides or other contaminants.

Hemp QualityIcon
Hemp Quality
15/20

Lazarus Naturals directly grows most of its organic hemp on a farm in central Oregon.

Extract TypeIcon
Extract Type
20/20

This CBD oil is made with full spectrum CBD, which contains all of hemp’s beneficial active compounds.

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests confirm that this CBD oil contains multiple minor cannabinoids.

PriceIcon
Price
10/10

This tincture costs $0.02 per mg of CBD, which is incredibly cheap. Additionally, Lazarus Naturals offers free shipping over $25 and a 60% discount to veterans, low-income families, and people with disabilities.

Pros: Cons:
  • Exceptionally low price
  • High CBD potency
  • Comprehensive third party testing
  • Lacks higher potencies

Best THC Free — Medterra Broad Spectrum Cannabinoid Tincture

Medterra CBD Cannabinoid Tincture 2000 mg

Overall Score
Product Review
88out of 100
$99.99 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
16/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 2000 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency66.67 mg/ml

Some people are sensitive to THC or have to pass drug tests for work, which means they can’t use full spectrum CBD products.

In that case, we recommend the ultra broad spectrum cannabinoid tincture from Medterra, which has a high potency of 67 mg per ml and three flavor options.

Quality AssuranceIcon
Quality Assurance
40/40

According to third party tests, Medterra’s tincture is free of contaminants and contains an accurate amount of CBD.

Hemp QualityIcon
Hemp Quality
15/20

Medterra’s CBD products are made from organic Kentucky hemp. The company is also certified by the U.S. Hemp Authority, which means it follows hemp industry best practices.

Extract TypeIcon
Extract Type
16/20

This tincture is made with broad spectrum hemp extract, which is free of THC but maintains all of the other beneficial compounds you’d find in a whole-plant product.

Additional ingredientsIcon
Additional ingredients
7/10

Third party tests confirm that this CBD oil carries minor cannabinoids that work together with CBD.

PriceIcon
Price
10/10

With a cost of $0.05 per mg of CBD, this tincture is priced lower than average.

Pros: Cons:
  • High CBD potency
  • Comprehensive third party testing
  • U.S. Hemp Authority certified
  • None

Best Topical — Nanocraft CBD Extra Strength CBD Muscle & Joint Stick

Nanocraft CBD Extra Strength CBD Muscle & Joint Stick - Broad Spectrum (500mg)

Overall Score
Product Review
83out of 100
$59.99 $0.12 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
34/40
Hemp Quality
15/20
Extract Type
16/20
Additional ingredients
10/10
Price
8/10
CBD Amount Score IconTotal CBD 500 mg
Available Bottle Sizes Score IconBottle Size 50 ml
Potency Score IconPotency10 mg/ml

Applying CBD topically is a great option when you’re dealing with muscle, skin, or joint inflammation in a specific area.

Our top pick for this category is the extra strength CBD muscle & joint stick from Nanocraft CBD, which contains 500 mg of CBD in a 50 ml container alongside multiple anti-inflammatory herbs.

Quality AssuranceIcon
Quality Assurance
34/40

Third party tests show that this product is free of contaminants, although it might contain more CBD than advertised.

Hemp QualityIcon
Hemp Quality
15/20

Nanocraft’s products are sourced from organic Colorado and Kentucky hemp.

Extract TypeIcon
Extract Type
16/20

This topical contains broad spectrum CBD, which has zero THC but still provides other beneficial cannabinoids and terpenes.

Additional ingredientsIcon
Additional ingredients
10/10

Nanocraft’s CBD stick contains many plant ingredients with anti-inflammatory properties, including cocoa seed butter, boswellia, cayenne extract, arnica, ginger, willow bark, and calendula.

PriceIcon
Price
8/10

Nanocraft’s CBD stick costs $0.12 per mg of CBD, which isn’t too bad considering its diverse formula.

Pros: Cons:
  • Added anti-inflammatory ingredients
  • Comprehensive third party testing
  • Not full spectrum

Best Capsules — Joy Organics CBD Softgels With Curcumin

Joy Organics CBD Softgels With Curcumin

Overall Score
Product Review
83out of 100
$89.95 $0.12 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
34/40
Hemp Quality
15/20
Extract Type
16/20
Additional ingredients
10/10
Price
8/10
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnitsNA
Potency Score IconPotency25 mg/ml

Many people prefer to use CBD capsules over oils because of their convenience. We recommend Joy Organics’ softgels with curcumin for dealing with inflammation.

Quality AssuranceIcon
Quality Assurance
34/40

Third party tests verify that these capsules are free of pesticides, although their CBD content may be higher than advertised.

Hemp QualityIcon
Hemp Quality
15/20

Joy Organics uses organic Colorado hemp for its CBD products.

Extract TypeIcon
Extract Type
16/20

These capsules contain THC free broad spectrum CBD.

Additional ingredientsIcon
Additional ingredients
10/10

These capsules carry 10 mg of curcumin, the main active ingredient of the anti-inflammatory herb turmeric. Third party tests also show that they contain minor cannabinoids.

PriceIcon
Price
8/10

These softgels cost $0.12 per mg of CBD, which is considered an average price. However, you’re also getting curcumin.

Pros: Cons:
  • Added curcumin
  • Comprehensive third party testing
  • Lacks higher potencies
  • Not full spectrum

Best Gummies — Five CBD Full Spectrum Gummies

five CBD CBD Gummies 25mg

Overall Score
Product Review
92out of 100
$39.99 $0.05 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
15/20
Extract Type
20/20
Additional ingredients
7/10
Price
10/10
CBD Amount Score IconTotal CBD 750 mg
Available Bottle Sizes Score IconUnitsNA
Potency Score IconPotency25 mg/ml

If you’re looking to use CBD gummies for inflammation, we recommend Five CBD. It offers one of the only full spectrum CBD gummies on the market. Each piece contains 25 mg of CBD.

Quality AssuranceIcon
Quality Assurance
40/40

Third party tests confirm that these gummies are free of contaminants, and they passed the test for CBD levels with results within the acceptable 10% variance.

Hemp QualityIcon
Hemp Quality
15/20

Five CBD’s products are made from organic American hemp.

Extract TypeIcon
Extract Type
20/20

Unlike most CBD gummies, these are made with full spectrum hemp extract.

Additional ingredientsIcon
Additional ingredients
7/10

According to third party tests, these gummies contain THC and multiple minor cannabinoids.

PriceIcon
Price
10/10

Five CBD’s gummies cost only $0.04 per mg of CBD. That’s cheaper than most other CBD gummies, especially since you’re getting a full spectrum product.

Pros: Cons:
  • Full spectrum formula
  • Comprehensive third party testing
  • High potency
  • THC content may be high for some people

Best Vape Product — CBDfx Terpene Vape Liquid

CBDfx Platinum Rose – CBD Terpenes Oil - 500 mg

Overall Score
Product Review
85out of 100
$49.99 $0.1 mg/CBD
Visit Site
Score Breakdown
Quality Assurance
40/40
Hemp Quality
18/20
Extract Type
12/20
Additional ingredients
7/10
Price
8/10
CBD Amount Score IconTotal CBD 500 mg
Available Bottle Sizes Score IconBottle Size 30 ml
Potency Score IconPotency16.67 mg/ml

If you’re looking for instantaneous effects, nothing beats vaping CBD. The best e-liquid we’ve come across is the terpene vape liquid from CBDfx. It comes in four flavors and two strengths: 500 mg (17 m/ml) and 1000 mg (33 mg/ml).

What makes this vape oil different from most is that it’s infused with a blend of cannabis terpenes for flavor and added effects.

You can buy it alongside CBDfx’s vape kit if you don’t have a vape.

Quality AssuranceIcon
Quality Assurance
40/40

According to third-party tests, this vape juice contains as much CBD as it should and is free of contaminants.

Hemp QualityIcon
Hemp Quality
18/20

CBDfx uses organic Kentucky hemp to extract CBD.

Extract TypeIcon
Extract Type
12/20

This vape juice contains pure CBD isolate.

Additional ingredientsIcon
Additional ingredients
7/10

Aside from CBD, this vape oil also contains a blend of cannabis terpenes for flavor and potential benefits.

PriceIcon
Price
8/10

CBDfx’s terpene vape e-liquid costs $0.07-0.10 per mg of CBD, which is cheaper than most CBD vape oils.

Pros: Cons:
  • Most reputable CBD vape vendor
  • Multiple flavors
  • Added terpenes
  • CBD vape kit available
  • Not full-spectrum

How to choose the best CBD for Inflammation

To find the best CBD product for inflammation you should consider a couple of factors:

  • Third party testing: This type of testing is done by an independent lab to verify that a product is free of contaminants and contains the correct amount of CBD. You should always check the test results for the product you want to buy.
  • Consumption method: Each way of taking CBD has its strengths and weaknesses. For example, topical products are the best option for localized inflammation, while CBD oil works best for whole-body relief.
  • Type of CBD: There are three types of CBD; isolate, full spectrum, and broad spectrum. Full spectrum is the most effective but if you need to avoid THC, you should use the other two forms.
  • Dosage: CBD affects everyone differently, so you’ll need to start at a low dose and slowly raise it to find your ideal dosage. Then, you can match the dosage to a product with the right potency.

These are just some of the considerations. Check out our detailed guide for a full breakdown of how to find reputable CBD brands and choose the best product for yourself.

Safety and side effects

Extensive research has shown that CBD is a safe substance with few and minor side effects. The most common ones include:

  • Tiredness and drowsiness
  • Dry mouth
  • Diarrhea and nausea
  • Low blood pressure and lightheadedness
  • Changes in appetite or weight

CBD can also interact with many prescription medications.

The good news is that these side effects are unlikely because they’ve only been reported by studies using high oral doses of pure CBD.

Still, we recommend talking to your doctor or another qualified healthcare professional before taking CBD, especially if you’re using prescription medicine.

Legality

Hemp derived CBD products (with 0.3% or less THC) are federally legal in the United States. However, a few states have more restrictive laws. Some ban CBD completely or only allow THC free products, so it’s best to research the particular state you’re curious about.

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About The Authors
Gleb Oleinik
Gleb Oleinik
CBD Journalist
Gleb Oleinik is a freelance health writer and Journalist from Vancouver, Canada. He’s read thousands of research studies about various supplement ingredients, enabling him to translate complex health information into simple language. Gleb specializes in CBD and has personally tried and reviewed dozens of CBD products. He’s knowledgeable about the ins and outs of the CBD industry as well as the science and research behind this popular natural remedy.
Eloise Theisen
Eloise Theisen
RN, MSN, AGPCNP-BC
Eloise Theisen is a board certified Adult Geriatric Nurse Practitioner who specializes in cannabis therapy. For over 20 years, Eloise has worked primarily with cancer, dementia and chronic pain patients. In the last 6 years, Eloise has focused her efforts on cannabinoid therapies. Eloise has worked with over 6500 patients to help them effectively treat age-related and chronic illness with cannabis.
CBD and inflammation
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